Sentence examples for multiple histone activation from inspiring English sources
The characteristic promoter-associated peaks for multiple histone activation marks (H3K9ac, H3K14ac, H3K4me2, and H3K4me3) were observed in Plasmodium.
We also observe that these phenotypes are distinct from the gene expression effects of a temperature sensitive allele of mst1, and suggest that multiple histone targets regulate gene activation in fission yeast.
Cells regulate transcription by coordinating the activities of multiple histone modifying complexes.
Moreover, activation of both CLDN3 and CLDN4 in ovarian cancer cells was associated with simultaneous changes in multiple histone modifications, whereas H3K27me3 loss alone was insufficient for their derepression.
Zhou et al. Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression.
Zhou, J. L. et al. Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression.
Thus, some cancers exhibit CpG island hypermethylation in combination with multiple histone modifications, such as deacetylation of histones H3 and H4, methylation of histone H3K9, trimethylation of histone H3K27, and a loss of trimethylation of histone H3K4 (Hamilton 2010).
Class I and II HDACs form complexes with multiple cofactors for activation where histones are a primary substrate [ 20] and have been targets for cancer therapies, including PrC [ 21].
ORCA interacts with multiple repressive histone lysine methyltransferases.
GAL gene activation is a complex process is involving multiple Gal4p activities, numerous positive and negative cofactors, and the histone tails.
Pang, M. et al. Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
