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The natural products Ybt and methanobactin appear to have solved this limitation by incorporating multiple heteroaromatic rings that maintain copper coordination while permitting superoxide interactions.
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Though all contained polycyclic heteroaromatic rings, these varied from two –to four-ringed structures.
The effects of substituent groups in heteroaromatic rings show considerable regularity.
Ruthenium species and compounds promoted hydrogenation of heteroaromatic rings in naphtha while rhodium complexes promoted hydrogenolysis.
The hydrogenation of (addition of hydrogen to) heteroaromatic rings is, by contrast, usually more difficult, for the heteroatoms tend to poison the catalyst.
Five- and six-membered heteroaromatic rings and their benzo-fused homologues are well established as important structural elements in drug design and are well represented in approved drugs.
Effect of chemical structures of heteroaromatic rings and electron-attracting groups on the molecular structures and melt properties of modified PP samples was studied.
Modification of the pendant 4-fluorophenyl group to various heteroaromatic rings was conducted aiming an interaction with the proximal amino acids, and then replacement of the morpholine ring was targeted for decreasing potential of time-dependent CYP3A4 inhibition.
The impact of aromatic ring count (the number of aromatic and heteroaromatic rings) in molecules has been analyzed against various developability parameters – aqueous solubility, lipophilicity, serum albumin binding, CyP450 inhibition and hERG inhibition.
Taken together, selective enhancement of cell death in prostate cancer cell lines and other aggressive cancer cell lines suggests that nitrogen-containing heteroaromatic rings are promising bioisosteres of the substituted phenyl ring in curcumin.
The rates of hydrogenation of the heteroaromatic rings were shown to be mostly influenced by the aromaticity of these rings (π-electron delocalization) and not by the basicity of the nitrogen atom.
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