Sentence examples for multiple hallmarks of from inspiring English sources

Table 1 describes the multiple hallmarks of cancer pathogenesis, respective cellular and molecular alterations, and associated targeted therapies.

Therefore, NF- κB inhibition may be an attractive strategy for cancer treatment through simultaneous inhibition of multiple hallmarks of EOC.

Thus, relative to PtenΔf or p53Δf single mutant, PtenΔf:p53Δf double-mutant claudin-low-like tumors exhibit multiple hallmarks of aggressive cancer.

Taken together, the above results suggest that the oocytes formed upon WEE-1.3 depletion exhibit multiple hallmarks of having precociously proceeded through the oocyte-to-embryo transition.

In fact, it is likely that a combination of markers will be required to give meaningful prognostic information to an individual patient, perhaps covering multiple Hallmarks of Cancer, rather than considering individual biomarkers in isolation.

The Sanger miRBase reports over 2000 miRNAs in the human genome and these miRNAs have indeed been shown to regulate multiple hallmarks of cancer, for example, increased proliferation and evasion of cell death (Ketting et al, 2001; He et al, 2005).

In summary, HKH40A targets multiple principal hallmarks of cancer, making it a perfect candidate for further preclinical and clinical testing.

Therefore, these results suggest the striking conclusion that multiple phenotypic hallmarks of brain aging are generated by aging-related modifications (weakening or strengthening) of selective GC signaling pathways.

In this study, we provide evidence that Met-driven oncogenic activation of Grb2 or Shc signaling leads to the neoplastic transformation of normal IECs and induces multiple redundant hallmarks of cancer in these cells.

Inflammation promotes multiple hallmark capabilities through a spectrum of bioactive molecules that are supplied to the tumor microenvironment in support of the hallmarks of cancer [ 13- 18].

We find that eight of them contain hallmarks of multiple clustered double-stranded DNA breaks (DSBs) on one or more chromosomes.