Sentence examples for multiple hallmark from inspiring English sources

Inflammation promotes multiple hallmark capabilities through a spectrum of bioactive molecules that are supplied to the tumor microenvironment in support of the hallmarks of cancer [ 13- 18].

Thus, our TO(Myc) line could serve as a good driving line for hepatocarcinogenesis. Upregulated Myc can affect multiple hallmark capabilities, such as proliferative signaling, energy metabolism, angiogenesis, invasion and survival (Hanahan and Weinberg, 2011).

Like other solid tumors, HCC is characterized with multiple hallmarks including sustained proliferation, evading growth suppressive signals, metastasis to other organs, promoting angiogenesis, tumor-promoting microenvironment, cancer stem cell properties, and energy metabolism switch, etc. Genetic and epigenetic alterations interplay during cancer initiation and progression.

Table 1 describes the multiple hallmarks of cancer pathogenesis, respective cellular and molecular alterations, and associated targeted therapies.

Therefore, NF- κB inhibition may be an attractive strategy for cancer treatment through simultaneous inhibition of multiple hallmarks of EOC.

Thus, relative to PtenΔf or p53Δf single mutant, PtenΔf:p53Δf double-mutant claudin-low-like tumors exhibit multiple hallmarks of aggressive cancer.

Some well-known cancer genes are hubs in the map, i.e., they appear in many pathways and influence multiple hallmarks.

Taken together, the above results suggest that the oocytes formed upon WEE-1.3 depletion exhibit multiple hallmarks of having precociously proceeded through the oocyte-to-embryo transition.

In fact, it is likely that a combination of markers will be required to give meaningful prognostic information to an individual patient, perhaps covering multiple Hallmarks of Cancer, rather than considering individual biomarkers in isolation.

DEHP (472) is also an endocrine disruptor (466, 467) that can impact multiple hallmarks such as immune evasion, resistance to cell death, evasion of antiproliferative signaling, sustained proliferative signaling and tumor-promoting inflammation (36, 288, 468, 469).

The Sanger miRBase reports over 2000 miRNAs in the human genome and these miRNAs have indeed been shown to regulate multiple hallmarks of cancer, for example, increased proliferation and evasion of cell death (Ketting et al, 2001; He et al, 2005).