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Finally, Vogwill and MacLean (2015) find evidence of both epistasis and antagonistic pleiotropy in their analysis of multiple genotypic datasets.
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Similar gaps have been effectively bridged, for example when relating multiple morphological traits (e.g. [20], [21]) and when relating multiple genotypic and phenotypic variables (e.g. [22]).
Prolonged DEB025 treatment and multiple genotypic changes may be necessary to generate significant resistance to DEB025, underlying the high barrier to resistance.
Additional file 2: Structure graphical outputs on 90 accessions based on different genotypic datasets.
As has been shown here and in other places [ 61, 62], multiple genotypic states can lead to the same phenotypic state.
Many methods combine multiple genotypic and phenotypic data sources, e.g. gene expression, protein interactions and overlapping disease characteristics (Doncheva et al., 2012a).
Often DNA is extracted mutliple times from a given individual and then multiple genotypic assays may be performed on each DNA or cDNA sample.
Our results suggest that genes affecting iron metabolism also affect lead metabolism, and this impact may be magnified by the presence of multiple genotypic variant alleles.
As V. vinifera genotypes are generally highly heterozygous [ 37], the unphased genotypic dataset was analysed to identify the succession of linked polymorphisms along the sequenced DNA region.
The quality of the genotypic dataset was assessed using M ICRO-C HECKER[ 38].
Multiparental mapping was performed using forward regression with family as a covariate and by fitting SNP effects as nested within family using the linkage genotypic dataset or by fitting SNPs as non-nested effects using the GWAS genotypic dataset.
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