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One of the most common copy number gains reported in multiple genomic studies of DIPG and pediatric GBM is that of PDGFRA [ 17, 18, 26].
Multiple genomic studies have identified single nucleotide polymorphisms on the CRF1 gene that are linked to depression, panic disorder, and PTSD [ 84- 89].
Recently Brannon et al. have integrated data from multiple genomic studies and have observed that one of the major sub-types clearly segregates along gender lines [ 24].
Moreover, it proves useful for identifying genomic markers with a common effect across multiple genomic studies due to its weak dependence on sample size variations.
Although plenty of gene expression data are publicly available now, it is challenging to integrate information of gene set enrichment analysis from multiple genomic studies targeting the same biological problem.
Complete distillation of the extensive findings of potentially causative mutations will require expression database analysis (e.g. http://hereditaryhearingloss.org/main.aspx c=.HHH&n=86597), functional assays in cell and animal models, meta-association analyses of integrated data from multiple genomic studies, and development of novel methods for discerning combinatorial effects of variants.
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The interplay of GATA3, ERα, and FOXA1 has been a topic of multiple functional genomic studies.
Some successful initiatives are: the investigation of galaxy morphology (Lintott et al., 2008), the prediction of protein structures (Cooper et al., 2010) and the alignment of multiple sequences in genomic studies (Kawrykow et al., 2012).
Although the prototypic two-domain BPIF protein, BPIFB1, has been identified in multiple proteomic and genomic studies (Barnes et al. 2008), information on the tissue localisation of the protein and its role in lung biology and disease is very limited (Bingle et al. 2010).
Moreover, genome-wide screening studies identified multiple genomic loci in PGIA [ 20, 26- 29] that are syntenic with those described in RA [ 25].
Several genome-wide linkage studies on height have been performed in recent years, and these studies suggest multiple genomic regions harboring genes affecting body height [2] [9].
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