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However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable manner is sorely needed.
The occurrence of substantially the same type 1 TnPZ at multiple genomic sites in Shimaa village strains, and of a similar element in the unrelated Italian strain G27 suggested that these elements are active and can be stable, potentially for the many thousands of years since H. pylori-infected humans migrated from Africa to the Eurasian continent, and eventually to The Americas [13], [52], [53].
Measurements from these non-specific probes likely represent a combination of DNAm from multiple genomic sites.
ChIP-seq experiments yield many ambiguous tags that can be mapped with equal probability to multiple genomic sites.
Remarkably, we did not find the highly conserved miRNAs miR855 and mir854 that are derived from retrotransposons at multiple genomic sites [ 42].
Ambiguous tags are those that can be mapped to multiple genomic sites, each of which has significant sequence similarity with the tag, and thus it is difficult to distinguish the real site from all the possible sites.
Similar(51)
For each ambiguous tag, there are multiple possible genomic sites to which it could be assigned.
Multiple ISWpi1 copies occur at various genomic sites in various Wolbachia genomes [19] [21].
The final dataset included 330,731 CpGs with probes that map to sex chromosomes, with known SNPs at the target site or that bind multiple genomic loci (defined from in silico analyses [ 36]) excluded.
We interrogated 10 genomic sites, including transitions between different satellite arrays and between satellite arrays and chromosome arms, across multiple X centromeres.
In such cases, the reduced specificity of the CRISPR Cas9 system, which may lead to the modification of genomic sites that are not identical to the sgRNA, can be harnessed for the simultaneous knockout of multiple homologous genes.
More suggestions(15)
multiple genomic deletions
multiple genomic locations
multiple genomic copies
multiple genomic regions
multiple genomic coordinates
multiple genomic changes
multiple genomic data
multiple genomic features
multiple genomic loci
multiple genomic datasets
multiple genomic matches
multiple genomic positions
multiple genomic resources
multiple genomic alignments
multiple genomic islands
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