Another surprise is that although the tiling probes are selected from the 'repeat-masked' genome, 1,215,226 (2.94%) of the probes have multiple genomic copies (Fig. 1).
Finally, exoglucanase was overexpressed in E. coli that carried multiple genomic copies of the celY gene.
Multiple genomic copies of Hps were also detected by real-time PCR analysis (not shown).
Recent work has demonstrated that there are multiple genomic copies of the MaSp1 dragline silk gene [ 8, 21, 34].
Phylogenetic evidence supports the notion that these duplication events leading to multiple genomic copies of RD genes have occurred independently in the deuterostome and ecdysozoan lineages.
For some of the most highly represented transcripts, we estimate multiple genomic copies suggesting a positive correlation between transcript abundance and genomic copy number, which may be a generalized dinoflagellate feature.
Among all frog LTR REs, Amn-san elements are the most abundant, with multiple genomic copies (>700) followed by Gmr1 and Kobel (Table 2); some of the copies show very low sequence divergence as indicated by the average relatedness values calculated on the basis of the nucleotide and aa sequences of the RT domain.
The variable domains of individual IG and TR chains are formed in lymphocyte precursors by somatic recombination of single discontiguous variable (V), diversity (D – in IgH, TRB and TRD chains only) and joining (J) genes selected from multiple genomic copies of these genes.
WRN was the top ranked gene associated with advanced clinical stage CRC; WRN was implicated by multiple genomic features - copy number alterations, methylation, and gene expression.
These genetic features were identified robustly in bootstrap resampling analysis.We conducted an analysis integrating multiple genomic features including mutations, copy number alterations, gene expression and methylation.
