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The software processes single nucleotide variants (SNVs) to identify and annotate putative splicing mutations with sufficient speed to analyze single or multiple genomes within a few hours.
The simultaneous analysis of multiple genomes within a single environmental sample also allows for assessment of selection acting on genes shared by members of the community.
Recent sequencing of multiple genomes within major branches of the tree of life provides a much greater selection of markers and excites hope that more accurate procedures for experimental design may be adopted.
The rapid development of high-throughput DNA sequencing technologies have allowed increasing numbers of genomes to be sequenced, especially multiple genomes within a genus, expediting the development of chromosome-specific markers and detailed comparative mapping.
We have developed a method of LOH analysis using case and unmatched control samples that differs from that which is currently available by directing the analysis cross-sectionally across multiple genomes within a cohort.
Comparing multiple genomes within this group can also clarify the Blochmannia pan-genome and let us reconstruct the likely gene content of ancestral genomes, thereby elucidating patterns of gene loss and erosion.
Similar(52)
As an alternative to whole genome or exome sequencing of tumor samples, it should be straightforward to barcode multiple independent targets of interest within a single genome or within multiple genomes.
Coevolution describes the evolutionary choice that enables similar proteins to either co-exist or not co-exist within multiple genomes.
Evidence of phase variation can be obtained by demonstrating repeat length polymorphism within multiple genomes from the same species, or closely related species as in this study.
We are aware of no other cases in which multiple genome rearrangements within a lineage have occurred by successive inversions of large blocks of protein-coding genes.
Therefore, it is still of great interest to develop principled methods for identifying chromatin states within and across multiple genomes.
More suggestions(15)
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