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Other researchers had previously found low frequencies of mutations in mitochondrial DNA as people age, but given that cells have hundreds of mitochondria, each with multiple genome copies, skeptics argued that the changes were not extensive enough to really hamper a cell's activity.
The presence of multiple genome copies could enable finishing a single cell genome, even if double-stranded DNA breaks were introduced during the single cell lysis step and handling for whole genome amplification.
Recently, it was reported that T. thermophilus is a polyploid organism, which harbors multiple genome copies per cell [ 50].
Thus, the ~3% probes with multiple genome copies could bring substantial influence to a ChIP-chip analysis.
Chloroplasts are usually uniparentally inherited and have their own genomes, with multiple genome copies per chloroplast, dense gene content, and slower evolutionary rates than those of nuclear and mitochondrial genomes (Wolfe et al. 1987; Drouin et al. 2008).
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To identify single-copy sequences, multiple genome equivalents of short SOLiD reads of another individual were mapped to shallow genome coverage of long Sanger or Roche 454 reads making up the reference sequence.
Obviously, the spheres contained complete genomes and probably multiple copies of them, because up to thirty genome copies can be present in growing cells of Halobacterium salinarum (Breuert et al., 2006).
Argiope spiders are not known to be polyploid, thus multiple gene copies per genome is the only explanation for more than two N- or C- terminal region variants in a single individual.
We determined that the gene families encoding glycolytic enzymes have single members that are frequently retrotransposed, resulting in the creation of multiple gene copies in the genome.
These two subfamilies contain TPS genes of primary plant hormone metabolism that are not typically represented with multiple gene copies in plant genomes [ 16, 33, 38].
Parasite genomes encoding multiple copies of the same VSAs are outcompeted by parasite genomes encoding the maximum number of distinct VSAs, consistent with high inter-locus diversity seen in the genome [6].
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