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Although accounting for up to 8% of human DNA, most of them have acquired multiple genetic mutations that made them harmless, and are usually considered as "junk" DNA.
These patients should consider a new method of testing for multiple genetic mutations via next-generation sequencing, which can often be ordered as part of a research protocol in academic centers.
Many other diseases, such as diabetes and hypertension, often stem from multiple genetic mutations, but researchers have struggled to identify the affected genes.
Simple chance may determine age of onset, because multiple genetic mutations are required for full tumorigenesis.
Sporadic cases of HPS associated with multiple genetic mutations have also been described [ 13].
Multiple genetic mutations appear to be required to cause proliferation and transformation of pVHL-deficient cells.
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Colorectal cancer arises through multiple genetic changes, including mutations of APC, TP53, RAS, and RAF (Kouzminova et al, 2010).
In this work we present a method to infer selection in an evolving population characterized by multiple genetic linkages between mutations at different loci.
BWS patients display multiple genetic and epigenetic mutations that mainly disrupt the expression of a cluster of imprinted genes located at human chromosome 11p15 (Cooper et al., 2005; Weksberg et al., 2005).
Though multiple genetic loci exist, mutations in the RPGR (RP GTPase regulator) gene account for >70% of XLRP and ∼20% of RP cases with no family history (30, 32).
It often arises through the accumulation of multiple genetic changes, including mutation of APC, K-ras and p53, but the frequencies of oncogene and tumor suppressor gene mutation in gastric cancer are relatively low, as compared those seen in colorectal cancer (2, 3).
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multiple genetic loci
multiple genetic models
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multiple genetic circuits
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multiple genetic conditions
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