Sentence examples for multiple genetic lesions from inspiring English sources

Mouse models of prostate cancer are used to test the contribution of individual genes to the transformation process, evaluate the collaboration between multiple genetic lesions observed in a single tumour, and perform preclinical intervention studies in prostate cancer research.

Our results support the concept that BPD, even in a genetically isolated family (Amish family 884), is a complex disorder and a combination of multiple genetic lesions likely contribute to its pathogenesis.

Molecular genetic analyses have demonstrated multiple genetic lesions implicating to pathogenesis of astrocytoma, glioblastoma in particular.

Experimental evidence supporting the hypothesis that multiple genetic lesions drive the histopathologic progression of transformed epithelial cells is also very convincing.

This is not unexpected given the advanced age of most MDS patients and the presence of multiple genetic lesions in diseased BM.

We focus not only on the utility of this method for forward genetics, but also its potential as a reverse genetics tool through accumulation of hybridization data for a collection of deletion mutants harboring multiple genetic lesions.

Because the comparisons are to tumors with high MYC expression that are likely to have suffered multiple other genetic lesions, these strategies reveal the transcriptional profile after all genetic lesions have occurred, not just those associated with MYC activation alone.

The transformation of EBV infection into a malignant disease is probably a result of viral reactivation in combination with other (epi genetic events, including the development of (multiple) cellular genetic lesions due to environmental carcinogens, food components, possibly combined with genetic immunodeficiencies [8], [13], [21].

The resemblance of CSCs to normal cell counterparts likely varies with regard to multiple factors, including the genetic lesions initiating tumorigenesis and progression, the tumor microenvironment, and the cell of origin of the tumor that is, the cell type in which oncogenesis occurs.

In contrast to BL, MYC rearrangement in DLBCL is often associated with multiple karyotyic aberrations and other genetic lesions [ 75].

Genetic lesions targeting multiple cellular pathways including T-lymphoid development, tumour suppression (FBXW7) and cell cycle regulation, as well as PI3-kinase/Akt (PTEN) and Ras (KRAS) signalling appear to be central events in the pathogenesis of T-ALL [ 11].