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In order to account for multiple genetic comparisons with 127 SNPs, statistical significance was defined as a P-value of <0.00039 based on Bonferroni correction.
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If there are many covariates and multiple genetic variants, then a hypothesis testing approach that accounts for the multiple comparisons may lead to a lack of power to detect any specific association.
It could deal easily with multiple genetic conditions where finding unaffected embryos is a challenge.
And early genetic comparisons reinforced this resemblance.
Multiple genetic modifications were made to the genome.
Tumorigenesis requires multiple genetic changes.
These fields are not focused on comparing genotypes of cells in any particular locus, but rather extract information from a general genetic comparison performed across multiple loci.
Genetic comparison of a collection of CA-MRSA using multilocus sequence typing (MLST) has indicated that strains with common features have arisen in geographically dispersed S. aureus strains with unrelated genetic backgrounds, indicative of multiple independent clonal origins [7].
Some of the genetic changes were observed in multiple tumor comparisons.
An integrative/comparative approach could help prioritize findings diluted by multiple comparisons from human genetic analysis.
Finally, not all of the genetic and transcriptomic studies in HAND have incorporated adjustments for multiple statistical comparisons, increasing the likelihood of false-positive findings amid true associations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com