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For the protein-coding sequences, codon-based models could not be used, as our phylogeny contains multiple genetic codes.
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Multiple factors, such as genetic codes, physicochemical properties, mutation-selection equilibrium, amino acid biosynthesis, etc, are likely related to the variation of amino acid usage in organisms [ 1, 2].
Data from the human genome sequencing project indicates the existence of multiple genetic variants altering the code for single amino acid residues distributed across the length of the TRPA1 and TRPM8 genes.
FHM belongs to the group of channelopathies and multiple genetic variants in three different genes coding for neuronal ion channels have been identified as causative.
6 Besides multiple genetic and epigenetic changes of protein coding genes in HCC, 2 growing evidence indicates that deregulation of miRNA can also contribute to HCC development by influencing cell growth, apoptosis, migration or invasion.
Osada and Wu (2005) indicated that the coding regions in human-chimpanzee ancestors had experienced multiple genetic changes during the speciation history of these species.
-- DNA isn't just for storing genetic codes any more.
"Ribosome Engineering and New Genetic Codes". Jason Chin, MRC Laboratory of Molecular Biology.
It could deal easily with multiple genetic conditions where finding unaffected embryos is a challenge.
Tumorigenesis requires multiple genetic changes.
Herein two genetic codes from which the primeval RNA code could have originated the standard genetic code (SGC) are derived.
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