Sentence examples for multiple genetic changes from inspiring English sources

But Dr. von Kalle said scientists believed that turning on just one oncogene would not be a problem because it usually requires multiple genetic changes to turn a cell cancerous.

Multiple genetic changes occur during the evolution of normal cells into cancer cells.

Cancer is a complex disease where multiple genetic changes rewire cellular networks during carcinogenesis.

Epidemiologic data and molecular biology have combined to demonstrate that multiple genetic changes may be required in carcinogenesis.

The precise mechanism of platinum-resistance is multifactorial and accumulation of multiple genetic changes may lead to the drug-resistant phenotype.

Tumorigenesis requires multiple genetic changes.

Our data that no significant correlation between ING2 expression and melanoma thickness or AJCC staging supports a multiple genetic change model during melanoma pathogenesis.

In several neoplasms it has been established that multiple sequential genetic changes are associated with the development of invasive tumours.

This provides a powerful tool to evaluate oncogenes in the context of tumor suppressor gene loss to more closely model the multiple, cooperative genetic changes that occur in glioma.

Given that resistance in most of these patients develops over a relatively short period of time (months, not years), it seems unlikely that resistance results from the accumulation of multiple individual genetic changes.

Multiple and progressive genetic changes accompanied by chromosomal aberrations are often the underlying cause [4].