However, most TFs are shared between multiple genes with varying binding affinities.
Furthermore, dCpf1-p300core proteins and dCpf1-SunTag system are able to simultaneously activate expression of multiple genes with a single gRNA targeting each gene.
Heat tolerance at flowering stage in rice is attributed to multiple genes with cumulative effects on trait expression, otherwise called as quantitative trait loci (QTL; Cao et al. 2003; Xiao et al. 2011a; Ye et al. 2012).
Estimating the different regions of QTLs in the reciprocal genetic backgrounds might be explained by the existence of multiple genes with the same function in the segment as a QTL cluster or epistasis with genetic background (Matsubara et al. 2016).
The effects were particularly pronounced for insects treated with RNAi against multiple osmoregulatory genes, i.e. combinatorial RNAi, suggesting that the partial silencing of multiple genes with related roles can yield greater functional impairment than RNAi against a single gene.
According to the CDC: "Scientists believe that many mental disorders result from the complex interplay of multiple genes with diverse environmental factors".
Blending of traits in the progeny is now explained by the action of multiple genes with quantitative effects.
Multiple genes with differential expression in the male and female rats, that were associated with fertility and reproductive tract morphology and function, were analyzed.
However, the model could be easily extended to include multiple genes, with gene-specific values of the basal and FOXO-stimulated transcription rate.
Despite its potential limitations this study identified multiple genes with significant or marginally significant associations with PTB in two separate samples.
Difficulty to identify genes that contribute to the risk of alcohol dependence likely reflects the fact that multiple genes with modest effects contribute to the development of this disorder.
