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Multiple genes, which confer selective advantage upon cancer cells such as tumor suppressors, adhesion molecules, inhibitors of angiogenesis and repair enzymes are silenced.
A News Feature on page 181 explores what we have learnt from these larger-scale studies about genetic risk of disease, particularly the development of risk scores involving multiple genes, which could help to guide preventive measures for some common ailments such as coronary artery disease.
Thus 2096-RD.2 has multiple genes which likely confer resistance to antimicrobial agents.
The classical operon has multiple genes which are transcribed from a single promoter [ 27, 28].
Phenotypic expression is influenced by multiple genes, which individually may increase or decrease the probability of disease development.
Genetic risk for MDD is considered to partially be manifested from multiple genes which interact with each other [ 44].
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Genomes of all Posibacteria encode multiple sortase genes, which have diversified to use multiple different substrate classes with different sorting signal motif sequences, and are involved in anchoring a diverse array of structures, including pili on the posibacterial surface [ 71].
After activation by ABA, SnRK2 mediates multiple reactions of the ABA pathway, including induction of transcription of multiple target genes which possess ABRE elements (ABA-responsive elements) in their promoters [ 11].
Disruption of multiple homologous genes, which have similar DNA sequences and gene function, is required for the study of the desired phenotype.
It will also allow breeders to develop varieties with enhanced disease resistance based on multiple resistance genes, which Reisch hopes will satisfy consumers and growers interested in organic or sustainable production.
In the nucleus, accumulation of TCF/β-catenin leads to transcriptional activation of multiple target genes, which can then contribute to development of cancer [5], [6].
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