All probe-sets annotated as recognizing multiple genes were removed.
Multiple genes were regulated coherently in response to energy restriction diets in females, but not in males.
Nowadays, multiple genes were identified to influence type 2 diabetes susceptibility, fasting and postprandial glucose levels [3], [4], [5], [6].
Only probe-sets that identified unique genes were utilized in this analysis and all probe-sets that identified multiple genes were discarded to control for potential cross-hybridization.
No functional categories containing multiple genes were found to be completely covered by diurnally regulated transcripts, and few functional categories were outstandingly enriched for diurnally regulated transcripts.
Further, in all cases in which multiple genes were hit with intact and deleted arms, the genes were closely related members of a single family.
Specifically, in the first twelve trials, a different gene was removed from the vector dataset, while multiple genes were removed from the vector dataset in the last three trials.
Multiple genes were significantly (p<0.01, at least two-fold) differentially-expressed between these stages (Table S5), when considerably more genes were upregulated (1908 probe sets, 1509 mapped genes) than downregulated (432 probe sets, 301 mapped genes) in the later stage compared to the earlier one.
Probe sets matching multiple genes were discarded.
Probes for multiple genes were eliminated.
Probesets mapping to multiple genes were excluded.
