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As underscored by Wood et al. [2], colorectal cancer is the product of mutations in multiple genes operating simultaneously.
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The "trait" genes that produce the human brain and nervous system are not fundamentally different from the "trait" genes operating in other mammals.
Highly enriched gene functions are frequently found in multiple distinct regions of the map, indicating major differences in their expression and hence the biological context in which the genes operate.
Our analysis suggests that genetic contribution to common inflammatory diseases operates through multiple genes interacting in functional pathways.
We suggest that the non-random patterns of LOH detected in cancer are a result of multiple different mechanisms operating to affect multiple genes, which may differ from tumour to tumour yet collectively play a role in the development of the tumorigenic phenotype.
The direct visual assessment of reporter gene expression enables the identification of functionally redundant genes, genes that operate in multiple developmental stages and genes whose functions in later development are obscured by an early lethal phenotype, all of them not easily amenable to classic genetic analysis.
All of the methods above operate on a single region or gene at a time, and, since multiple genes can contribute to disease risk, we propose instead to analyze all genes simultaneously in a regression framework.
They traced this trait to multiple genes on five chromosomes.
We now know that multiple genes influence every phenotype.
(A) Schematic depiction for simultaneously targeting of multiple genes.
Perenniality is a complex trait, controlled by multiple genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com