Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
The use of multiple genes not only increased the support for species delimitation, but it also provided more information to improve the precision of the coalescent estimates of divergence time and assessment of the degree of genetic isolation.
The use of multiple genes not only provides a greater resolution over different time scales but yields a more accurate estimate of the species tree which may not correspond to a single gene tree, especially in radiations of closely related species [ 4, 5].
However, as the majority of studies had only targeted one or a few genes in rather small patient groups, the concurrent hypermethylation behavior of multiple genes has only been addressed in a limited number of tumor types, such as colorectal cancer.
Despite near-multiplicative effects for most loci, and the fact that groups with very high relative risk of type 1 diabetes can be identified by testing for multiple susceptibility genes, only a small proportion of the population (and cases with type 1 diabetes) simultaneously carry HLA and multiple non -HLA susceptibility genotypes.
Probes with an absent or marginal call in more than 90% of samples were omitted as were array tags linked to multiple genes, and only the highest SAM ranked probe for a gene was included.
Since Circos plots and enrichment heatmaps are two visualization tools specifically designed for multiple gene lists only, and a bar graph is only used for a single gene list, we estimated that 70% of the published studies studied a single gene list and 30% studied multiple gene lists.
The β and γ crystallins are each also represented by multiple gene copies, only some of which are expressed exclusively in the lens.
A considerable amount of research reveals, however, that complex phenotypes, such as antisocial behavior, are probably due to multiple genes acting not only independently, but also interactively.
Individuals could acquire multiple gene copies only through duplication.
