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To determine the cumulative impact of multiple genes on one trait, the authors assumed they could simply add together the impact of individual genes.
Two additional datasets, both of which have multiple genes on at least one chromosome, are analyzed in the Supplementary Materials.
We show here that multiple genes on chromosomal segment 4q12 are amplified in a subset of MPNST and one MPNST cell line.
They traced this trait to multiple genes on five chromosomes.
However, simultaneously modulating multiple genes on the chromosome remains challenging in prokaryotic organisms, including the industrial workhorse - Escherichia coli.
These results proved that by positioning multiple genes on different chromosomes, fine-tuning of cellular metabolism could be achieved in recombinant S. cerevisiae.
Similar(38)
An analysis of quantitative trait loci (QTL) has confirmed that most male color traits are controlled by multiple genes, including genes on autosomes (Tripathi et al. 2009b).
Finally, it is likely that multiple genes located on different chromosomes may influence ethanol consumption and this may contribute to differential correlations between this trait and DOC suppression by dexamethasone.
Activated FoxO3a can upregulate multiple genes depending on the apoptotic stimuli.
For the individual-level analyses, the most severe consequence was selected for variants that affected multiple genes based on the functional impact class supplied by CAVA.
To further study the gene space and especially the genes clustered in islands in more detail, we considered gene islands as multiple genes located on the same BAC or overlapping BACs, i.e. separated by less than 150 kb.
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