Using segregation analysis, a group in Cambridge UK have derived a susceptibility model – the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) model – in which susceptibility is explained by mutations in BRCA1 and BRCA2 together with a polygenic component reflecting the joint multiplicative effect of multiple genes of small effect on breast cancer risk.
Instead, most now agree that such illnesses are most likely "oligogenic," mediated not by a single gene, but by multiple genes of smaller effect acting in combination with one another and the environment.
It is a complex genetic disorder, influenced by multiple genes of small effect.
We find jumping genes and multiple genes of one sort coding for different protein isoforms.
Essential hypertension (EH) and cardiovascular disease are common, multifactorial disorders likely to be influenced by multiple genes of modest effect.
The colony PCR quick prep provides sufficient usable DNA template such that this assay could be readily expanded to assess multiple genes of interest simultaneously.
DT40 is an avian leukosis virus-induced chicken B cell line with an exceptionally high ratio of targeted to random DNA integration, which enables efficient targeted disruption of multiple genes of interest.
QTL mapping is designed to detect multiple genes of small effect, has the potential to find new genes related to alcoholism, and is useful for inferring a cause and effect relationship between a gene and a trait.
Difficulties arise for identifying the multiple genes of variable effect that interact with nongenetic factors in more common, complex conditions and for understanding the physiological processes associated with the development of these phenotypes.
Since the multiple genes of roots are found to have spatial and temporal differences in their expression and function, the search for the trait differences, genes and their function need to be expanded with large set of mutant resources (Wei et al. [2013] for a review).
Genome-wide association studies and admixture mapping are approaches that remain to be applied to TB, and it is not clear, as is the case with other complex diseases, how much of the heritability of the TB susceptibility phenotype will be determined by multiple genes of small effect versus rare variants with disproportionately large effects.
