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Rather it seems likely that common familial psychiatric disorders result from the combined effect of multiple genes none of which is either necessary or sufficient to cause the condition [ 20].
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Based on these and on other data, current researchers favour a synthesis of the two theories, in which the combination of the trisomy of multiple HSA21 genes, none of which is by itself critical for the disease, induces a wide-range cascade of events that through physical and functional interactions engages many non-HSA21 genes and results in a global remodeling of genomic function.
However, if we correct for multiple tests (255 genes), none remain significant.
Of note, although there are studies investigating multiple genes and multiple cancers, none of them formally considers this as a two-dimensional selection problem.
All three possible relationships among these major angiosperm clades have been generated based on single and multiple gene trees, but none receives strong support in any of these studies [reviewed in [ 25]].
Although multiple genes containing internal inverted repeats are found in S. cerevisiae (Verstrepen et al. 2005), none are in this convergent tandem orientation that potentially allows for diversity to be generated by inversions between repetitive sequences.
They traced this trait to multiple genes on five chromosomes.
We now know that multiple genes influence every phenotype.
(A) Schematic depiction for simultaneously targeting of multiple genes.
Perenniality is a complex trait, controlled by multiple genes.
Complex traits can arise from the interactions among multiple genes.
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