Except GBSSI for AC, SSIIa for DEC and PGWC, RGS1 for GL and LWR, other marker-trait associations only explained less than 15%% of the phenotypic variation of a trait, indicating that accumulating desirable alleles of multiple genes is necessary for achieving sizable improvement.
However, it is also evident why signatures of multiple genes are necessary to achieve high class predictive accuracies in heterogenous clinical populations that are the reality of transplantation medicine.
The HIF complex activates the transcription of multiple genes that are necessary for the Warburg effect to occur [12].
These results also imply that the simultaneous loss of multiple genes may be necessary for disease initiation and progression of del(5)(q31.2) associated MDS and AML.
So future studies with large sample size on analyzing multiple genes may be necessary to explain the SNPs interaction.
Due to the lack of resistant germplasm, and the fact that the resistance is possibly mediated by multiple genes, it is necessary to identify and explore the genes that contribute to plant resistance against S. sclerotiorum[ 38- 42].
While rational metabolic engineering was effective in improving phenotypes of S. cerevisiae strains for xylose fermentation [ 4], it normally involves the constitutive expression of multiple genes followed by necessary mutagenesis and post-evolutionary engineering.
Instead of comparing measurements of a single biological marker between disease and control groups, multivariate analyses are based on the notion that several variables of a certain type (such as the expression level of multiple genes) may be necessary in order to discriminate between disease and normal states.
Abd-B-like HOX transcription factors, like HOXA10, can form dimers or trimers with TALE proteins that thereby regulate the multiple HOX downstream target genes necessary for the implantation process.
However, the practicality of design and the biology of the immune response may require that variable sites in multiple gene families are necessary as targets.
