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The sheer complexity and tight regulation of this multistep process apparently requires engagement of active alternative splicing for multiple genes, especially transcriptional factors in germline.
Sox2 regulates expression of multiple genes, especially stable expression of Oct-3/4, which is also a transcription factor that maintains stemness and pluripotency in normal stem cells.
The etiology remains unclear, but the prevailing disease model is that multiple genes, especially HLA-DRB1 alleles, interact with environmental risk factors, including tobacco smoking, culminating in an adaptive immune response to citrullinated autoantigens that perpetuates joint inflammation [ 1].
The activity of HOTAIR is due, in part, to the interaction of HOTAIR with the polycomb repressive complex 2 (PRC2), which comprises the histone H3K27 methylase EZH2, SUZ12, and EED and enhances H3K27 trimethylation to decrease the expression of multiple genes, especially metastasis-suppressing genes (Rinn et al, 2007; Gupta et al, 2010; Tsai et al, 2010).
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We found that Demodex mitochondrial genomes share the following features with other members of the Acariformes: (1) they are compact in size and AT-rich; (2) they have experienced multiple gene rearrangements, especially among the tRNA genes; and (3) they have many truncated tRNA genes.
While Kluyveromyces marxianus is a promising yeast strain for biotechnological applications, genetic engineering of this strain is still challenging, especially when multiple genes are to be transformed.
Of 80 bacterial species detected of having carbapenemase genes, 15 had multiple genes coding for carbapenem resistance especially in E. coli and P. aeruginosa.
Observed variations in transcript abundance are therefore likely to be biologically meaningful, especially if multiple genes within the same pathway are simultaneously affected.
Previously the BPH resistance cultivars were mainly bred by traditional breeding approach, which generally led to time- and labor-consuming and low efficiency, especially for pyramiding multiple genes.
Second, in some cases, especially within gene families, multiple genes will share the same tag sequence.
We restricted the analysis to LGT genes with especially strong matches and to instances where multiple genes were transferred together and gene order was conserved.
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