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Recent years, multiple genes contributing to abiotic stress responses in rice were identified by using genetics, reverse genetics, and molecular biology method.
1/ MS is a complex genetic disease with multiple genes contributing with probably modest effects to disease susceptibility.
While the involvement of single gene mutations in individual autism cases cannot be excluded, the concept of a complex genetic model with multiple genes contributing to disease susceptibility remains highly plausible for the majority of cases [10].
Multiple genes contributing to mammalian folliculogenesis have been identified in mouse knockout study [ 56].
Epistasis involves multiple genes contributing to a single phenotype, but the biological nature and implications of epistatic interactions are not always clear.
The decrease in the concordance rates of siblings compared with the rate among monozygotic twins supports the presence of multiple genes contributing to the autoimmune phenotype onset.
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A multiplicative model for risks, appropriate for rare diseases, assumes that the multiple genes contribute to a genetic risk score, assumed to be approximately normally distributed in the population, risk being related to this genetic risk score via a log-link function.
It is hoped that future genetic and neurobiological studies will provide better insight into how multiple genes contribute to the common epilepsies.
The absence of an increased burden of smaller CNVs in individuals with autism and the failure of most large hotspots to refine to single genes is consistent with a model where imbalance of multiple genes contributes to a disease state.
This mutational robustness could arise either due to redundancy, i.e. direct backup, or due to distributed architecture, i.e. indirect backup where multiple genes contribute to the functioning of a process in the system.
If we consider the genetic regulation of the immune response, multiple genes contribute to the response to any pathogen - some acting as positive and others as negative regulators [5] (Figure 1).
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