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Most of the fatty acid synthesis and degradation proteins of P.putida LS46 had multiple genes coding isozymes i.e. FadB had 4 isologs, FadA had 5 isologs and FadD had 7 isologs for short and long chain fatty acids.
In Cluster B, multiple genes coding for the E. coli type three secretion system apparatus (i.e. escT, escS, escU, and escR) were up-regulated.
Therefore, for risk prediction to be clinically useful, a composite model is needed that estimates the combined effect of "conventional" risk factors and genetic variants in multiple genes coding for proteins acting alone or interacting with each other [22].
Because of the existence of multiple genes coding for gliadins along with those encoding LMW-GS proteins in the chromosomal regions harboring Glu-3 loci [26], an important task for the future will be to dissect the physical, genetic and functional relationships of the two types of seed storage proteins.
PolyQ proteins are also known to influence the transcription of multiple genes coding for important mitochondrial proteins.
Furthermore, we were able to more reliably characterize the expression of multiple genes coding for isozymes, isoforms with different cellular location and enzyme subunits.
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CNV can affect gene expression levels, since it contains or disrupts multiple gene coding regions or regulatory elements, which could then lead to phenotypic variation [ 19].
It is possible that this high value of non-synonymous polymorphism observed for the secreted class may result from chimeric assembly of coding sequences originating from multiple recently duplicated genes coding for very similar proteins.
Indeed, analysis of the genome revealed multiple copies of genes coding for σI-like factors and their cognate membrane-associated RsgI-like (anti-σI) factors, which may be involved in regulatory mechanisms of cellulosomal and related cellulase genes.
The Lysobacter strains had a different activity spectrum against fungi, oomycetes and bacteria (Fig. 3; Additional file 3: Table S4), suggesting that they harbour or express different or multiple sets of genes coding for antimicrobial compounds.
We present a tool for the genome-wide analysis of frequencies and patterns of amino acid substitutions in multiple alignments of genes' coding regions, and a database of amino acid substitutions in the phylogeny of 12 Drosophila genomes.
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