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If chromatin ubiquitination is important for regulating the balance between mutagenic and faithful DNA repair in Ig gene hypermutation, one might predict that AID could deaminate multiple genes but the resulting uracils are faithfully repaired at the non-Ig loci.
Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Initially, studies combined clinical characteristics with aberrant DNA methylation at single or multiple genes, but genome-wide DNA methylation profiling of thousands of CpG sites is now leading to the identification of prognostic signatures.
Moreover, we demonstrated that these vectors can be used not only to produce different siRNA to simultaneously suppress the expression of multiple genes but also to maximize the silencing of a singe gene.
Reads with equal mapping score towards multiple genes but with imperfect sequence alignment were retained for further analysis since this level of similarity is expected among different HLA genes.
Most regions contained multiple genes but a few were small enough to allow identifying potential driver genes mentioned in Additional file 1. High quality RNA was available for 46 of the 135 tumors.
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Effective genetic screening in future may require gene chip or other techniques to assess multiple genes concurrently, but this should not replace a multidisciplinary approach to these often difficult cases.
All genes are off (S-3-1), Only Gata1 and Scl are expressed (S-2-1) And An interconnected set of 32 expression states with multiple genes active but Gata1 always repressed (S-1-1 to 32).
Dynamic modelling revealed that the experimentally validated network topology allows for three stable states (Fig. 2A): All genes are off (S-3-1), Only Gata1 and Scl are expressed (S-2-1) And An interconnected set of 32 expression states with multiple genes active but Gata1 always repressed (S-1-1 to 32).
Several authors have attempted to predict GC disease and prognosis based on single or multiple genes [ 3- 8], but there are discrepancies between the studies, and currently no gene signature or biomarkers are in routine clinical use.
The omics sciences allow scientists to study the integration of information as it occurs in the body by looking at multiple genes or proteins, but also produce abundant data.
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