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Multiple genes as well as proteins that seem to play a central role in EMT have so far been identified and are either up- or downregulated during the process, thus serving as possible markers in the assessment of EMT.
Moreover, most MTLE cases look sporadic and may be influenced by variations in multiple genes as well as by environmental factors.
Alcoholism (also: alcohol dependence) is a complex, heterogeneous disorder that is influenced by multiple genes as well as sociocultural factors [ 1, 2].
ASD, like other complex disorders such as diabetes and heart disease, is almost certainly associated with the effect of multiple genes as well as environmental factors.
We employed the CRISPR/Cas9 system and developed methods for one-step generation of mice carrying mutations in a single or multiple genes, as well as mice carrying reporter and conditional alleles (Wang et al. 2013; Yang et al. 2013).
At the S-locus region, the S-RNase gene is always surrounded by the S-pollen gene(s), that can be one gene as in Prunus (called SFB; [ 32- 37], or multiple genes as in Pyrinae (called SFBBs; [ 38- 45, 47] 47], and Solanaceae (called SLFs [ 14, 46, 47]).
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Generally, however, we reserve the term complex for phenotypes that are influenced by multiple genes (polygenic) as well as environmental factors.
We noted significant, coordinated coexpression of multiple target genes, as well as coordinated promoter demethylation, in a large set of individual tumors that was associated with the SCC subtype of NSCLC.
We have not determined how extensive the duplication is, but it presumably involves multiple flanking genes as well.
Having to identify single genes, not extended regions with multiple linked genes as would be required for analysis of synteny, overcomes a practical difficulty that not all sequenced genomes have been completely assembled yet.
Multiple gene loss as well as intron gain and loss events have also occurred, highlighting the instability of the perforin gene in the teleost fish.
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