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Emerging techniques for high-throughput single-cell analysis (allowing for heavy and light chain pairing) will soon be adapted to sequence multiple genes along with the BCR, and eventually the full genome.
The other 95% are each related to a subtle interplay of many different genes and other factors.For instance, diabetes and heart disease two of the biggest killers today are caused by complex interactions of multiple genes, along with environmental factors such as smoking, exercise and diet.
On the other hand, small changes could be important when multiple genes along a given pathway are affected.
Putting together the results from linkage, genome-wide association and sequencing studies, the genetic architecture of Crohn's disease represents that of a typical multifactorial complex trait where a combination of multiple genes, along with the environment, lead to disease.
On the other hand, if u(maxMCC =FALSE, then there are multiple genes along with O that have the same maximum of MCC, and therefore the additional measure AUC is invoked.
Additional studies are also needed to characterize the combined effects of multiple genes along with demographic and clinical variables in selecting the appropriate opioid and predicting the appropriate opioid dose in patients with pain.
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Because of the existence of multiple genes coding for gliadins along with those encoding LMW-GS proteins in the chromosomal regions harboring Glu-3 loci [26], an important task for the future will be to dissect the physical, genetic and functional relationships of the two types of seed storage proteins.
Of note is that there are several cases of subfamily expansion due to multiple gene duplications along a single gene lineage.
It is worth mentioning that in theory topological discordance between gene trees could also result from the coexistence of multiple gene copies along internal branches of the species tree.
Multiple alignment of 8 P. xylostella chymotrypsin genes along with HaChys 1-3 and OnChys 1-3.
Multiple alignment of 38 P. xylostella trypsin genes along with well annotated trypsins: Aedes aegypti trypsin 3A1 (Anopheles, Anopheles gambiae trypsin-6 (AgTry6), Culex quinquefasciatus trypsin1 (CqTry1) and trypsin5 (Cqtrypsin5
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