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We extended our pairwise analysis to multiple gene order comparisons.
In short, RSBs are non-redundant, maximal representatives for a set of multiple gene order alignments.
We used EnsEMBL database annotations (release 50) for 17 high-coverage genomes to construct multiple gene order alignments.
We selected 17 high-coverage vertebrate genome assemblies from the EnsEMBL database (release 50) to run multiple gene order comparisons.
Our new software, CYNTENATOR, computes multiple gene order alignments progressively in a bottom-up approach along a given phylogeny.
We propose a method, called CYNTENATOR, to discover conserved syntenic regions over large evolutionary distances by progressive multiple gene order alignment.
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We improved on the efficiency of our approach by recasting it into a profile-profile alignment setting, which is an extension of the Waterman-Eggert algorithm [21] to the comparison of multiple gene orders.
There is an increasing demand for plants bearing mutations in multiple genes in order to dissect the functions of gene family members with redundant functions and to analyze epistatic relationships in genetic pathways.
Multiple different gene orders found throughout the mt genome, utility as phylogenetic markers and the unknown causes and mechanisms associated with gene duplication and subsequent retention and/or removal of sequences, calls for the determination of complete mt genomes over single genes.
Alper et al. (2005a) developed a procedure that sequentially screen the effect of single and multiple gene deletions in order to select those enabling the best product yields while maintaining sufficient growth rates.
It is likely that the TSER genotype would be used in conjunction with other TYMS variants and as part of a multiple gene panel in order to better individualise therapy.
More suggestions(15)
multiple gene cassette
multiple gene change
multiple gene duplication
multiple gene function
multiple gene modification
multiple gene transformation
multiple table order
multiple gene expression
multiple gene delivery
multiple gene association
multiple gene microarray
multiple integral order
multiple gene conversion
multiple gene transfer
multiple gene family
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