Sentence examples for multiple gene modifications from inspiring English sources
For multiple gene modifications, multiple sgRNAs can be used to disrupt multiple genes.
In conclusion, the Cas9/gRNA system is a highly efficient and fast tool for generating gene KO in rabbits and can be utilized to construct multiple gene modifications in 1 step.
Efficient multiple gene modification can be achieved by a single electroporation of various Cas9 mRNAs (Ren et al., 2017).
As a result, engineering a desired phenotype would be facilitated enormously by simultaneous multiple gene modification, yet the capacity to introduce such modifications is very limited.
Among them were mutations in p53, RB1 and in multiple genes regulating histone modifications (CREBP, EP300 and MLL), which may also offer a novel therapeutic approach for these tumors.
We will see new genetically engineered farm animals produced by homologous recombination, multiple gene editing in one-step generation and conditional modifications, among other advancements.
The co-occurrence of modification and remodeling has significantly different influences on multiple gene features compared with presence of either one.
Exhaustively exploring combinations of genetic modifications is both experimentally and computationally inefficient, and can become intractable when multiple gene deletions or insertions need to be considered.
Given that many genes cooperate in various pathways, incorporating multiple gene cassettes in tandem in a transgenic DNA construct for the purpose of genetic modification is often necessary when generating organisms that produce multiple foreign gene products.
Therefore, questions regarding the efficacy of gene transfection as well as safety and maintenance of multiple stem cell traits after gene modification need to be answered in greater detail for the effective utilization of stem cells in treating human diseases.
The multiplicity of β-glucosidases in filamentous fungi is common and is often due to the presence of multiple genes, or differential post transcriptional modifications [ 42, 43].
