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Patients were excluded if they had active infections, second primary malignancies, uncorrected hypercalcemia, or an LVEF ≤ 45% measured by multiple gated acquisition (MUGA) scan.
Repeated multiple gated acquisition scans or two-dimensional (2D) echocardiograms revealed decreased cardiac ejection fractions (left ventricular ejection fraction [LVEF] ≥ 20% versus baseline) in six patients.
All patients had baseline history, physical examination, complete blood counts, electrolytes, blood urea nitrogen, creatinine, liver function tests, electrocardiogram, multiple gated acquisition scan (MUGA) and tumour measurements by relevant radiological investigations.
Assessments of left ventricular function with multiple gated acquisition scanning or echocardiography were performed every four cycles until the maximum cumulative dose of anthracycline was reached, and every two cycles thereafter.
The use of multiple gated acquisition scans for pretreatment screening appears to be more cost-effective for patients who are 40 years or older, when cumulative doxorubicin dose is 350 mg m−2 or less.
Cardiac function was determined before treatment and was monitored by electrocardiography, by Multiple Gated Acquisition scan, or by echocardiography on day 22 after initiation of therapy to assess potential cardiotoxicity.
Similar(46)
Variations in the cure rate differences between the doxorubicin and alternative regimens had insignificant effects on the improvement in 5-year survival rates from multiple gated acquisition-scan screening.
For patients who received up to 350 mg m−2 of doxorubicin, multiple gated acquisition-scan screening had an incremental cost of $425 402 per life saved for patients between the ages of 15 39.
This study was designed to prospectively investigate the effects of total or partial chordal-sparing and chordal-nonsparing mitral valve replacement (MVR) procedures on regional and global ventricular function in a rheumatic population using sequential multiple-gated acquisition scan.
Multiple-gated acquisition (MUGA) scan and echocardiogram are used for determination of LVEF in breast cancer patients before and after chemotherapy [64].
A multiple-gated acquisition (MUGA) scan is particularly useful for determination of the ejection fraction in HL patients before and after they undergo chemotherapy.
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