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This sequence conservation is likely consistent with the multiple fundamental roles that CLE peptides play in plant development.
NOTCH signaling has multiple fundamental roles in cancer, where, among other activities, critically regulates stem-like cancer cells and contributes to hypoxia responses, epithelial-mesenchymal transition (EMT), angiogenesis and invasiveness [ 50, 57].
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4, 5 miRNAs play fundamental roles in multiple biological processes, including cell proliferation, differentiation, and apoptosis.
In addition to its primary roles in pHi homeostasis and cell volume regulation, a substantial body of evidence indicates that NHE1 has fundamental roles in control of multiple cellular processes, including cell proliferation, cell death/survival balance, cell mobility, and a wide variety of cell signalling transduction.
The complexity of their fundamental roles as key mediators in multiple body systems, beyond the regulation of blood volume, is well documented, and it appears that the regulation of sKATP in the myocardium is an extension of this axis.
While proteins play fundamental roles in gene expression, RNAs have also been found to regulate multiple points of control, namely transcription, RNA degradation, and translation.
In human life, smells play a variety of fundamental roles.
Condensin plays fundamental roles in chromosome dynamics.
Considering the critical role of AMPARs in the central nerve system function and neurobiological diseases, regulation of their dynamical trafficking by S-palmitoylation also serves as a predominant determinant of multiple fundamental brain functions and pathological process.
Many ribosomal proteins play fundamental roles in ribosome assembly [ 5].
KATP channels play fundamental roles in cellular physiology.
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