In this study, we proposed to directly use an external annotation database such as the KEGG pathway to extract multiple functionally compact and coherent gene sets.
Alternatively, one can use the external annotation database such as Gene Ontology to directly guide the selection of multiple functionally compact and coherent gene subsets (modules) as we did in a recent study [ 18].
Our spatial analysis of DNA methylation and hPTMs reveals a strong patterning of multiple, functionally distinct hPTMs and RNA pol II relative to methylated regions.
Posttranslational modifications modulate protein function, and HTT is subject to multiple functionally relevant modifications including SUMOylation, ubiquitination, acetylation, palmitoylation, and phosphorylation (for review, see Ehrnhoefer et al., 2011; Pennuto et al., 2009).
Further, strain C1A co-transcribes multiple functionally redundant enzymes for cellulose and hemicellulose saccharification that are mechanistically and structurally distinct.
It is likely that no single TF will be sufficient to fully restore neuron-intrinsic growth potential, and that multiple, functionally interacting factors will be needed.
It included RNA samples, expected to be highly variable on their gene expression profiles, since amygdalae comprise multiple functionally distinct nuclei [ 29], and micro-punching of such regions in mouse brain is inherently imprecise.
The discovery and characterization of multiple, functionally distinct forms of Mediator characterized by the presence or absence of the Cdk8 kinase module have led to new insights into how Mediator functions in both Pol II transcription activation and repression.
We show that multiple, functionally specialized cohesin complexes mediate the establishment and two-step release of sister chromatid cohesion that underlies the production of haploid gametes.
Thus, it remained unclear whether the associated markers all reflect the same functional variation or, more likely, multiple functionally important variants are present in a large region encompassing DAOA/G72 [ 5].
