Thus, it remained unclear whether the associated markers all reflect the same functional variation or, more likely, multiple functionally important variants are present in a large region encompassing DAOA/G72 [ 5].
Posttranslational modifications modulate protein function, and HTT is subject to multiple functionally relevant modifications including SUMOylation, ubiquitination, acetylation, palmitoylation, and phosphorylation (for review, see Ehrnhoefer et al., 2011; Pennuto et al., 2009).
Accelerated point mutations lead to fine-tuning of target specificity, whereas ASSET leads to large-scale replacement of multiple functionally important residues, resulting in change or gain of functions.
One objection could be that the IFC is an extensive anatomical structure that houses multiple functionally distinct sub-regions.
Jones, B. F., Groenewegen, H. J. & Witter, M. P. Intrinsic connections of the cingulate cortex in the rat suggest the existence of multiple functionally segregated networks.
This boundary is composed of multiple functionally redundant elements and has two key activities: it blocks crosstalk between iab-6 and iab-7 and facilitates boundary bypass.
For many design problems, multiple functionally equivalent software versions have failure correlation even if they have been independently developed.
However, the dACC contains multiple, functionally specific subpopulations of neurons25, including nociceptive-specific ones26 and those that code for various motivationally relevant events, such as reward expectancy27 or predicted cognitive demands28.
The complexity of having multiple functionally relevant variants that differ widely across populations together with the limited information available did not allow us to include it in our dopaminergic brain function index.
Our results demonstrate that although the IFC is a heterogeneous structure that houses multiple functionally distinct sub-regions, none of these sub-regions is functionally unique within the brain.
It is likely that no single TF will be sufficient to fully restore neuron-intrinsic growth potential, and that multiple, functionally interacting factors will be needed.
