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We found that the axon of an SG EIN forms multiple functional synapses on the dendrites of a postsynaptic neuron.
We show that axon of an SG EIN forms multiple functional synapses on dendrites of a postsynaptic neuron.
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Therefore, aripiprazole has been regarded as a unique 'functionally selective' ligand [ 36, 42]; that is, a drug that may show different intrinsic activity at different receptor subclasses in the synapse, or that may cause multiple functional effects, even when interacting with the same receptor.
The collagen-entrapped NSCs/NPs recapitulate CNS stem cell development and form functional synapses and neuronal circuits.
Furthermore, the decrease in dendritic spine density was correlated with the decrease in the number of functional synapses.
Therefore, these data indicate that neuritin increases the number of functional synapses, possibly by promoting the maturation of synapses.
Thus, the modulation of specific synapses coupled with increased potential apical synaptic connections may result in greater functional synapses.
Loss of AMPAR from spines may result in conversion of functional synapses into silent, non-functional synapses (Lo and Erzurumlu, 2007).
In other studies, areas with both presynaptic and postsynaptic proteins have revealed no functional synapses [ 83].
Slice electrophysiology and optogenetics proved that these connections represent functional synapses.
Accumulation of amyloid-beta leads to loss of functional synapses in Alzheimer's disease.
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