The interplay of GATA3, ERα, and FOXA1 has been a topic of multiple functional genomic studies.
DS has been investigated with multiple functional genomics studies aiming to understand the molecular basis underlying the various aspects of the disease [ 4- 7].
However, double and triple combinations of mir-48, mir-84 and mir-241 mutations cause developmental defects, revealing biological roles for these family members and stressing the importance of the analysis of multiple homologous miRNAs during functional studies.
We report the synthesis and the functional studies of multiple crown α-helical peptides designed to form artificial ion channels.
Integrating genomic data with functional studies in multiple cell lines, we demonstrated that ERG and ESE3 controlled in opposite direction transcription of the Polycomb Group protein EZH2, a key gene in development, differentiation, stem cell biology and tumorigenesis.
Functional studies in multiple malignancies suggest that BMP4 typically causes reduced growth and increased migration of cancer cells [ 5].
Here, we validated the efficacy of our generic EMT scoring system to reflect the EMT transition in a panel of functional studies across multiple cancer types.
The availability of complete collections of easily moveable cloned ORFs facilitates functional studies in multiple species in parallel, even at the level of whole proteomes.
Although recent genome-wide association studies have identified several genetic variants contributing to the complex aetiology of multiple sclerosis (MS), expression and functional studies are required to further understand its molecular basis.
The economic and scientific importance of these fungi has led to whole genome sequencing and functional studies of multiple economically important and phylogenetically related Fusarium species including, F. graminearum (Fg), F. verticillioides (Fv), F. oxysporum (Fo), and F. solani [ 4- 8].
