Sentence examples for multiple functional polymorphisms from inspiring English sources

Sequence comparison further revealed that multiple functional polymorphisms cumulatively resulted in the conversion from Pish-mediated race specific resistance to Pi35-mediated non-race specific resistance (Fukuoka et al. 2014).

These independent associations could indicate either multiple functional polymorphisms, or a complex pattern of medium-range LD reflecting differing patterns of recombination in ancestral populations carrying the risk variant, or both.

In addition, multiple functional cis-regulatory polymorphisms in the same gene have already been found in loci associated with other complex diseases [ 37- 39].

Stepwise regression was performed to examine the effect of multiple alleles with different functional polymorphisms on the HI traits, and to estimate the total variance explained (R 2 ), using the lm function in R [ 37].

The approach was to associate DNA polymorphisms at multiple functional candidate loci with natural phenotypic variation in advanced tetraploid varieties and breeding materials.

In an interesting paper, functional polymorphisms relating to MHC-molecule expression were demonstrated to be associated with susceptibility to RA, multiple sclerosis and myocardial infarction [ 47], suggesting putative common mechanisms.

However, a number of functional polymorphisms in- or close to the COMT gene have been described, and some recent studies have looked at multiple single nucleotide polymorphisms (SNPs) and different COMT haplotypes in relation to psychiatric phenotypes [ 38, 39], and interaction between the COMT gene and other genes [ 26, 33].

Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism.

MiRNA-polymorphisms (miR-polymorphisms or miRSNPs) are a novel class of functional polymorphisms present in the human genome [33], [34].

It is also possible that these SNPs are not the functional polymorphisms but are linked to a functional polymorphism elsewhere in the gene.

The VDR harbours several known functional polymorphisms.