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In principle, these tools should lead to mechanistic understanding of evolutionary trajectories, but selections for faster growth or novel functions typically produce adaptive mutations in multiple functional modules (Kvitek and Sherlock, 2013), whose relationship to each other is hard to explain.
Systems biology analyses identified multiple functional modules, active kinases, transcription factors and connectivity between them, and mitochondrial pathways including mitoribosomes and complex IV.
The combination of multiple functional modules into a single nanocarrier can increase the intracellular delivery of many drugs, genes, and proteins, which might enhance their therapeutic efficacy [15 17].
The system is developed by integrating multiple functional modules, which include a reliable navigation module that provides reliable position and heading information, a robust autopilot module enabling Springer tracking well the waypoints and an intelligent path planning module that is capable of generating feasible and practical waypoints.
Presence of a protein in multiple functional modules in addition to its high connectivity implied that any changes regarding protein would affect all its functional modules.
Our structure-guided analyses show that these interspersed CRY-interacting regions represent multiple functional modules of PERs at the CRY-binding interface.
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It is further based on the hypothesis that the cancer phenotype is based on the inability of multiple genetic functional modules to carry out their basic functions, and that functional modules are critical to the "hallmarks of cancer", including self-sufficiency in growth signals, evasion of apoptosis, sustained angiogenesis, tissue invasion and metastasis [14].
This is biologically sensible, as many genes and proteins are known to participate in multiple functions, and hence functional modules can overlap with each other.
Since some proteins participate in multiple complexes or functional modules, a number of approaches allow overlapping clusters.
Human proteins may have multiple functions and belong to different functional modules, so different signaling pathways may also have some pathway members in common.
Another area of significant progress is multiple network alignment tools, e.g. Grælin developed by Flannick et al. [ 30], which uses a probabilistic function for topology matching, and can be applied to search for conserved functional modules among multiple protein interaction networks.
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