Comparative transcriptomics analysis suggested that the AZFP in the mutant exerted beneficial effect by modulating the expression of multiple functional genes.
Except for the platypus, all mammals have at least one functional RNase1 gene, and four species (rat, guinea pig, cow, and little brown bat) have multiple functional RNase1 genes (table 1 and fig. 4 A).
We are developing analysis algorithms that will enable us to assign probabilities for the existence of particular virulence mechanisms in an unknown organism, using the unique discriminative power afforded by a multiple-family functional gene array.
In contrast, our approach is fully automated and handles multiple functional annotations per gene.
Due to the high redundancy that exists between pathway databases coming from multiple functional annotations of gene products, pathway enrichment often results in a long list of potentially interesting pathways.
While multiple functional categories of genes were altered in expression, we focused on the significant differential expression of numerous genes in signalling pathways promoting cell development, differentiation and survival, with a concomitant decrease in programmed cell death associated genes.
Some results suggest that multiple functional variants from genes in neurodevelopmental pathways contribute to development of SZ [ 8], while the biological mechanism is undefined.
The authors describe the concept of using dose response curves based on multiple functional variants in genes of pharmaceutical interest in order to prioritize molecular targets in drug development.
An advantage of the methodology presented here is that ExomeWalker quickly shows whether there are candidate genes with both predicted pathogenic variants and multiple functional associations with other genes in the same disease-gene family.
Importantly, it will show all first- and second-degree interactions with the seed genes, allowing users to quickly eyeball candidate lists to determine if there are genes with multiple functional associations with the seed genes that would reward closer inspection.
