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Initiation of Hox gene transcription requires interaction among numerous factors recruited to the target gene, particularly to the multiple functional elements, so as to establish their precise domain boundaries in the developing tissue [26].
Chunking is a process commonly believed to play a role in perceptual, motor, and cognitive sequence learning during which multiple (functional) elements are integrated into one larger 'chunk' [65] [68].
We found that this limited set of gap insertion effectively helps to capture composite motifs with multiple functional elements.
The MMP-9 promoter is highly conserved and contains multiple functional elements, including nuclear factor-κB (NF-κB) and activator protein (AP -1 elements [ 8- 10].
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The intracellular region harbors multiple conserved functional elements including nuclear localization signals, a RAM (RBP-J-association module) domain, ankyrin repeats involved in protein interactions, a trans-activation domain and a C-terminal PEST (praline/glutamic acid/serine/threonine) domain that regulates protein stability (Kopan and Ilagan, 2009).
The promoter of the human MMP-9 gene contains multiple functional cis-regulatory elements including AP-1, NF-κB, Sp-1, Ets-1, and Egr-1 elements, which are involved in baseline and induced transcriptional responses [ 43, 46, 50].
The design approach applies redundancy to functional elements and specifies multiple, common, low-permeability materials to ensure reliable performance.
High conservation of noncoding sequences across multiple species may indicate the presence of functional elements.
We obtained genome-wide functional elements which were characterized by multiple epigenetic marks using a Hidden Markov Model [ 29] from UCSC genome browser, such as strong or weak enhancers and transcriptional elongation.
Several studies suggest multiple functional roles for DNA methylation, including silencing of transposable elements, mediating developmental gene regulation and reducing transcriptional noise.
Accumulation of evidences for their multiple functional roles including regulation of transcription and stimulation of recombination and splicing elect them as functional elements.
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