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Since the overall representation of genes and corresponding annotated functions in the entire rat genome may confer a bias in this type of functional classification and because a single gene may belong to multiple functional categories, one major challenge is to distinguish processes and functions specifically associated with epileptogenesis from those found due to random chance.
Co-expression analysis indicated significant enrichment of the CBSGs and ALSGs in multiple functional categories suggesting their involvement in a wide range of biological functions.
hRMN allows the assignment of multiple functional categories while avoiding common problems in annotation transfer from heterogeneous datasets, such as an independency of the investigated datasets.
Because proteins can have multiple functional categories, the frequencies do not add up to 100%.
These proteins fell into multiple functional categories including protein synthesis, energy metabolism, and protein fate (Table S5).
Within the top ten most significant gene set overlaps, multiple functional categories associated with development were strongly enriched within our differentially methylated gene list.
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We have developed a system that combines a unique collection of data from multiple functional annotation categories to prioritise variants by predicted function.
Recent examination of proteins in model bovine chromaffin secretory vesicles revealed multiple functional protein categories that participate in secretory vesicle production of neuropeptides and catecholamines for cell cell communication (Fig. 7) (49, 49).
It is noted that IPA functional analysis did not identify any down-regulated genes from these datasets as specifically associated with ciliogenesis, and although multiple significant functional categories were identified, no specific biological process within these categories took prominence (data not shown).
In contrast, all of the published studies reported multiple enriched functional categories.
As shown, the clusters were involved in multiple biological functional categories.
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multiple functional peripheries
multiple functional domains
multiple functional groups
multiple functional regions
multiple functional layers
multiple functional properties
multiple functional queens
multiple functional structures
multiple functional forms
multiple functional synapses
multiple functional copies
multiple functional STs
multiple functional proteins
multiple functional manifestations
multiple functional processes
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