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Hepatocyte growth factor (HGF) has been known as a multiple function factor, which also stimulates early haematopoiesis.
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Signal transmission in a cellular system may have multiple functions: transcription factor activation, which may be related to the cell cycle, to morphological change or to adjustment of protein concentrations, cytosolic kinase/phosphatase activation with multiple cellular targets, membrane protein activation such as ion channels or receptors, etc.
Given the multiple functions of many inflammatory factors, it has been difficult to pinpoint their roles in specific (patho physiological situations.
Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with multiple functions through its type I (TGFBR1) and type II (TGFBR2) receptors.
Progranulin (PGRN) is an autocrine growth factor with multiple functions.
The nucleocapsid (NC) protein is an essential factor with multiple functions within the human immunodeficiency virus type 1 (HIV-1) replication cycle.
Basonuclin is a transcription factor with multiple functions.
The multiple functions of the YY1 transcription factor in the nervous system have been recently reviewed [226], [228], and enhanced transcription of the proteolipid protein (PLP), one of the most abundantly expressed myelin proteins, has also been observed [229].
Pleiotrophin is a heparin binding secreted soluble factor with multiple functions in various systems [ 29, 30].
CCAAT/enhancer binding protein delta was increased, and is a transcription factor with multiple functions, that is positively related to myostatin expression in mammals [ 95].
Nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ), an adipose tissue-specific transcription factor, exerts multiple functions in adipose tissue.
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