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The multiple follicle thyroid model used in this work is a simplification, with a single spherical layer of follicle cells surrounding the central follicle and the neighbouring follicle lumen simulated as a spherical shell around the outer cell layer.
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The mean absorbed dose calculated for our human thyroid multiple follicle model, assuming homogenous distribution of for 123I, 125I, or 131I within the follicle lumens and follicle cells, was 9%, 18% and 4% higher, respectively, compared with the mean absorbed dose according to Medical Internal Radiation Dose (MIRD) formalism and nuclear decay data.
A multiple thyroid follicle model was used to calculate the contribution from surrounding layers of follicles to the follicle cell nuclei in a centrally placed follicle, based on the previously published multiple follicle model [[19]].
For radioiodine homogeneously distributed in the follicle lumens our calculations for the human multiple follicle models gave up to 90% lower mean absorbed dose compared with MIRD formalism.
Figure 3 Mean absorbed dose for different distributions of radioiodine in the human multiple follicle model.
For radioiodine homogeneously distributed in the follicle cells and lumens, calculations for our human multiple follicle model gave up to 18% higher mean absorbed dose.
Thus, the single follicle thyroid model, maybe supplied with one surrounding follicle layer, is a simple and realistic model when studying radionuclide emitting particles with ranges up to that of alpha particles, while more follicle layers are needed for particles with longer range.
Light microscopic examination of sections of thyroid gland showed; multiple follicles filled with acidophilic homogenous colloid.
It is showing multiple follicles filled with homogenous acidophilic colloid (Co).
Figure 8C compares these parameters for each of the four arbor types that contact multiple follicles.
Gonadotropins are hormones that stimulate your ovaries to produce multiple follicles (cysts that contain eggs).
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