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In patients where multiple fluid challenges must be repeated in a short time, this inevitably leads to administering a volume of fluid that is far from negligible.
Even though these studies were limited by the multiple fluid challenges performed in a limited number of patients/animals, these results suggest that pulse-pressure variation should cautiously be interpreted in patients with pulmonary hypertension.
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There may be multiple fluid domains and multiple solid domains.
Results Forty-two fluid challenges were realized in 17 patients.
This is why repeated fluid challenges may potentially lead to fluid overload.
bTwenty-eight fluid challenges included.
aTwenty-two fluid challenges included.
Thirty-four fluid challenges were performed.
Adequate fluid resuscitation should be achieved using repeated fluid challenges.
Repeated fluid challenges therefore can lead to fluid overload.
Thirty-three fluid challenges (41.2%) significantly increased MAP.
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