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By contrast, the measure of glucose variability introduces the possibility that multiple fluctuations of blood glucose could be more dangerous than either chronic stable hyperglycemia or a simple episode of acute hyperglycemia.
However, the concept of glucose variability, even taking the above evidence into consideration, is more complex a phenomenon because it introduces the idea that multiple fluctuations of glycemia in the same individual could be more harmful than a simple episode of acute hyperglycemia or, indeed, chronic stable hyperglycemia.
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i) The level of DNA damage, D: is assigned from a normal distribution with a given average μ D and a standard deviation σ D. The variation in D might arise from multiple sources: fluctuations in concentrations of DNA repair enzymes, variations in metabolic load (and subsequent Reactive Oxygen Species (ROS) production) in single cells, etc.
Plants rely on transcriptional dynamics to respond to multiple climatic fluctuations and contexts in nature.
Therefore our analysis does not address important nonlinear dynamical behaviors arising in many physical and biological systems, such as noise driven transport between multiple quasiequilibria, fluctuation induced spiking in excitable systems (including noise induced spiking in nerve cells), or limit cycle oscillations (including regular spiking in nerve cells).
The energy spectra in the dayside magnetosheath show (frac {1}{f}) spectral scaling indicating the existence of multiple sources of fluctuations.
The results also demonstrate that food webs can remain intact for a long time--hundreds of generations--despite multiple and varied fluctuations in their member species.
The multiple timescales of fluctuations in excitability are meant to mimic the different sources of noise in the nervous system, and we assume that each timescale contributes equally to the total fluctuations in excitability.
Multiple, inconsistent, unsystematic fluctuations in azithromycin concentrations in PBMCs and PMNs over time were observed in individual participants, particularly after 48 hours.
Azithromycin blood concentrations peaked early (median Tmax of 3.5 hours) and declined biexponentially with time, whereas azithromycin concentrations in PBMCs and PMNs were much more variable, with a later peak (median Tmax of 9.0 hours in PBMCs and PMNs), as well as multiple, inconsistent, unsystematic fluctuations in individuals, particularly after 48 hours.
This fluctuation may occur within a single patient (intraindividual variation) and/or across multiple individuals (interindividual variation).
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