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Multiple flares of arthritis were induced with an intra-articular injection of SCW in the hind ankle on day 1, followed by intravenous challenges on days 21 and 42.
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Multiple pregnancies, and thus multiple deliveries, can lead to multiple flaring episodes of the clinical signs of chronic hepatitis C, which, in turn, can lead to liver cirrhosis and carcinogenesis among women; a concept that is supported by our present results.
If a patient experienced multiple flares, the first was used for classification.
If you are lighting the flare for roadside use, you should place multiple flares well behind the vehicle, so that oncoming traffic has time to move over.
Multiple, discrete flares of increased pain were experienced by nearly all individuals recovering from acute LBP.
Patients with acute LBP report multiple distinct flares of pain, which correspond to discrete increases in pain intensity.
Patients with acute LBP often have multiple distinct flares of pain in the six weeks after seeking care, and these flares correspond to discrete increases in pain intensity relative to periods not in flare.
Taken together, this model facilitates the assessment of anti-rheumatic agents targeting inflammation and pain in the multiple flare paradigm and offers a powerful tool for drug discovery.
-Chronic recurrent multifocal osteomyelitis (CRMO): CRMO is a non-bacterial, auto-inflammatory disease characterized by recurrent flares of inflammatory bone pain related to presence of multiple foci of aseptic osteomyelitis [22].
Furthermore, flares of pain occur even after pain has largely improved, and for many individuals, multiple discrete episodes of transient pain worsening occur.
When exposed to repeated DSS cycles to induce chronic colitis akin to the flares of inflammation in IBD, Gpa33 −/− mice were less able to resolve multiple bursts of epithelial damage and inflammation than WT controls.
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