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However, other genes were repeatedly observed in multiple families affected with different phenotypes (e.g. DST).
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However, BRCA1 and BRCA2 mutations are only identified in about 15 20% of multiple-case families affected by breast cancer alone [ 1, 2].
Thus, the average over multiple families is affected by the number of available fully sequenced viruses in each family.
About 10-20% of breast cancer cases are family clustered, with multiple family members affected by the disease [ 2].
Conway's toast was mostly about the families affected.
More often than not, studies rely on single-country analyses and employ simplistic notions of transnational family life associated with which parent migrates (mother, father or both) and whether or not they remit, thus hindering the effort to understand how multiple characteristics of transnational families affect children's health.
To date there is no report of multiple family members being affected by FGD and FSGS.
Compound heterozygosity (N468D/A1105T) was observed by Pagnamenta et al. (2006) in another 3-generation family in which multiple family members were affected with both PEO and POI.
Maternal and paternal family histories of diabetes are both associated with an earlier age of onset (2– 4), and this effect is more marked when multiple family members are affected (5).
Due to history of multiple family members being affected (Fig. 2) by AML and extra genital warts (sister, son, and daughter), congenital lymphedema (son), and cytopenias (sister) a work-up for familial bone marrow failure syndromes was carried out.
There are reports of multiple family members being affected by FSGS in association with other hereditary disorders like Charcot-Marie-Tooth disease [ 14], Laurence Moon Biedl syndrome [ 15], Craniomandibular Dermatodysostosis [ 16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com