Interestingly, we identified multiple virulence factors implicated in the pathogenesis of invasive enterococcal infections.
No canonical pathways (as defined by mSigDB) were shared, but there were multiple transcription factors implicated in the transcriptional phenotype of both mutants (Fig. 9C).
100 More recently, Cav-1 has been shown to participate in a reciprocal, positive feedback loop with multiple growth factors implicated in prostate cancer progression.
Additionally, analysis of the 5′ flanking region shows SaCD79α lacks a TATA box and possesses binding sites for multiple transcription factors implicated in its B cell-specific gene transcription in other species.
Multiple factors are implicated in the etiology of the enlargement and divided into two categories: mechanical and biological factors (Wilson et al., 2004).
Since multiple factors are implicated in the pathogenesis of Alzheimer's disease (AD), there is growing interest in finding multi-targeted agents to treat the disease.
Although the mechanisms that contribute to muscle dysfunction are not completely understood, multiple factors are implicated, such as systemic inflammation, oxidative stress and nutritional deficits (Decramer et al., 2005).
As the number of biomarkers for microbial agents and disease markers [10] increases, simultaneous detection of multiple agents or risk factors implicated in particular clinical syndromes or diseases that share similar epidemiological features will become highly desirable.
A 5 10% weight loss induced by a negative energy balance (i.e., calorie restriction, endurance exercise, bariatric surgery) simultaneously improves multiple metabolic and hormonal factors implicated in the pathogenesis of several lethal chronic diseases, as well as in the biology of aging itself (Goldstein, 1992).
